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Stimulation of appetite and preservation and increase of muscle mass: Anabolic steroids have been given to people with chronic wasting conditions such as cancer and AIDS. The aim of this systematic review is to investigate these effects on appetite and muscle mass.

INTRODUCTION:

Since the first publication on the physiological effect of testosterone on human growth hormone levels in 1972, testosterone has been used as an anabolic agent to increase muscle mass. The aim of the research was to determine if testosterone administration enhances appetite and whether this effect is related to alterations in muscle mass.

RECENT FINDINGS:

Severity of anabolic-androgenic steroid use was shown to be associated with weight loss in patients treated for obesity or diabetes mellitus [1] and to increase lean body mass among overweight and obese patients [2]. However, no previous research has examined these effects on human subjects with regards to appetite. For instance, it is unclear whether oral testosterone (which is not regulated by gastric emptying and has an immediate stimulating effect on appetite) affects appetite, appetite-related hormones, body weight regulation or body composition [2]. To our knowledge, there has been only one study that evaluated appetite-enhancement from anabolic androgenic steroid use in patients with obesity [3].

METHODS:

This systematic review examined the efficacy of testosterone administration on appetite and body composition in overweight and obese men and women. The main sources of data examined were: clinical trials, observational studies and reports of the European Food Safety Authority.

RESULTS:

There are many studies published on the physiological effect of testosterone on appetite or increased appetite-related growth hormone (GH) levels, but very few on the effect of testosterone administration on body weight. The effect of testosterone administration on appetite should be evaluated in two main categories: (a) those that directly test appetite or appetite-related hormones (adipoietic hormones, glucose, GH), (b) those that assess body fat mass (lean mass) and/or body composition (muscle mass).

CONCLUSIONS:

There is, at present, no conclusive evidence of the effect of testosterone administration on appetite. No published trials are available to evaluate the effect of testosterone administration on weight maintenance. No published trials have investigated effect of testosterone administration on appetite and body composition in overweight and obese patients.

© 2015 Elsevier Ireland Ltd.

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