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Sixty elderly men were put on various Ostarine dosages for 3 months, and it was found that simply taking 3mg of Ostarine per day led to an increase in muscle mass by 1.2% for the group that took the full Ostarine dose. By the time the Ostarine dosage had ended, the group that took the full dose had experienced an increase of 1.2% in muscle mass.
Ostarine is also used in cases of chronic anxiety, like the one I wrote about below and in which the patients took a full dose of 50mg twice a day for one month and experienced an increase in strength from 15 minutes to nearly five as well as improvements in sleep patterns.
Ostarine has a slightly more complicated chemistry. It’s not just some sugar molecule like glucose or beta carf. In fact it possesses a few unique properties in addition to the glucose/beta carf ones, mainly as a ligand for the mammalian cannabinoid-1 receptor. This receptor plays a central role in the regulation of energy metabolism, and one of the main functions of this receptor is the synthesis or degradation of certain neurotransmitters, of which dopamine and GABA are two examples. Indeed, it was found by one of my colleagues (John-Paul Sommers) that there are two groups of the cannabinoid-1 receptor:
Group 1 receptors, which exist in many tissues including neurons/nerve fibers, are critical for the control and regulation of energy metabolism, as for example they signal when cellular energy requirements are too much, and control whether or not energy is actually consumed.
Group 2 receptors exist in mitochondria and have a critical role in the maintenance of cellular activity (e.g. respiration, and the release and transport of energy-laden chemicals from mitochondria to other tissues), are critical for maintaining cellular energy homeostasis. Indeed, the receptors are so critical for energy homeostasis that it was discovered that blocking this energy-sensing receptor leads to a severe metabolic slowdown in muscle cells.[2]
One of the ways in which they’re associated with a slowdown with exercise is by acting on the CB1-R, so Ostarine has been tested in the lab with exercise, and showed promise. This drug was taken for the first time and was tested to see if it would act on the receptors in the muscle, and it did indeed. They tested it on various animal samples, and saw the same effects with the exercise. This was thought to be an unexpected and unexpected finding, and Ostarine was in preclinical clinical trials for over a decade, with no success. A big mystery was why no one noticed this effect prior to this.
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