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The North American and Eastern European studies also included high-dose Toremifene arms of 200 and 240 mg daily, respectively [see Clinical Studies (14)]. Adverse Reactions North American Eastern European Nordic FAR60 TAM20 FAR60 TAM40 FAR60 TAM40 n=221(%) n=215(%) n=157(%) n=149(%) n=214(%) n=201(%) Cardiac Cardiac Failure 2 (1) 1 ( Ocular* Cataracts 22 (10) 16 (7. Eastern European and Nordic studies: AST, alkaline phosphatase, and bilirubin ‘ WHO Grade 1 (1. Other adverse reactions included leukopenia and thrombocytopenia, skin discoloration or dermatitis, constipation, dyspnea, paresis, tremor, vertigo, pruritus, anorexia, reversible corneal opacity (corneal verticulata), asthenia, alopecia, depression, jaundice, and rigors. The incidence of AST elevations was greater in the 200 and 240 mg Toremifene citrate dose arms than in the tamoxifen arms. Higher doses of Toremifene citrate were also associated with an increase in nausea. 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