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With hundreds of human studies proving its efficacy, it’s no surprise that creatine is the most used and respected bodybuilding supplement along with protein powders. There’s many peer-reviewed studies which show how creatine effectively increases testosterone (T) and dihydrotestosterone (DHT) in human subjects ( 18 ) ( 19 ) ( 20 ) ( 21 ) ( 22 ). Grape seed extract is a potent estrogen blocker. This is due to the fact that two compounds in GSE; proanthocyanidin and procyanidin, can both inhibit the aromatase enzyme. Furthermore grape seed extract is a potent antioxidant protecting testosterone molecules from oxidative damage ( 23 ). The best way to take grape seed extract is on an empty stomach, as it has been found that the amount of proanthocyanidin/procyanidin in the bloodstream was roughly 5 times greater in a fasted state than in a fed state ( 24 ) Rhodiola Rosea lowers stress and balances hormones. Rhodiola Rosea is the most beneficial adaptogenic herb the human race has discovered to date which grows in the harsh conditions of Northern Asia and Siberia. Since it’s an adaptogen, it’s often used in lowering stress, and to balance hormones. By lowering stress and thus cortisol, it is able to boost testosterone on a recurring basis ( 25 , 26 ). There’s no direct proof that it boosts testosterone, however at the very least it could improve the C:T ratio in exercising humans, and significantly lowers all the parameters of stress. When evaluating side effects of testosterone boosters, there are fundamentally two potential categories of adverse effects. The first are the immediate adverse effects of the ingredients, like fenugreek seed or horny goat weed. Some common ingredients in testosterone boosters, like vitamin D, are not known to have adverse effects even in very high doses. Others, though, like horny goat weed, yohimbe, and ginkgo biloba, do have some evidence connecting them to adverse effects. Horny goat weed, for example, has been reported to be associated with tachycardia (a rapid, racing heart rate) in rare cases ( 27 ). Yohimbe and ginkgo biloba have been reported to be associated with mood changes, anxiety, and addictive behavior, particularly among people who are predisposed to emotional and mental health disturbances ( 28 ). Use of testosterone boosters is discouraged in people under age 18, as reported in an article in the journal Pediatric Clinics of North America ( 29 ). While use of testosterone boosting supplements in teenagers is widespread, virtually no research has been conducted into their safety or efficacy in people under 18, so the risk-benefit profile is far less well-understood. The second category is the adverse effects of increased testosterone itself. Scientific research has definitively established that increased testosterone levels lead to increased lean body mass, but it can also cause increases in aggression and irritability, at least in individuals who are predisposed to this type of behavior ( 30 ). These adverse effects are not seen with controlled doses of (pure) testosterone over short periods of time, however’generally they occur with very high doses taken for long periods of time, and the connection between high doses of pharmacological grade testosterone with supplemental testosterone boosters is far from clear. The precise dose of a testosterone booster for maximum efficacy is obviously going to depend on the specific formulation. With the most common ingredients, like vitamin D, magnesium, and zinc, the effective dose can be roughly compared to the recommended daily intake for that vitamin or mineral, buy gp bold 300 mg injectable steroids equipoise, eq. When it comes to herbal compounds, the picture is less clear. 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