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High-risk women were defined as women who have a 1. In this study: Out of every 1000 high-risk women who took a placebo , each year about 7 got breast cancer. Out of every 1000 high-risk women who took tamoxifen , each year about 4 got breast cancer. The study showed that on average, high-risk women who took tamoxifen lowered their chances of getting breast cancer by 44%, from 7 in 1000 to 4 in 1000. In this study: Out of every 1000 women with DCIS who took placebo , each year about 17 got breast cancer. Out of every 1000 women with DCIS who took tamoxifen , each year about 10 got breast cancer. The study showed that on average, women with DCIS who took tamoxifen lowered their chances of getting invasive (spreading) breast cancer by 43%, from 17 in 1000 to 10 in 1000, buy test-plex 300 mg injectable steroids $47.00 sustanon (testosterone blend). These studies do not mean that taking tamoxifen will lower your personal chance of getting breast cancer. We do not know what the benefits will be for any one woman who takes tamoxifen citrate to reduce her chance of getting breast cancer. What are the risks of tamoxifen? In the studies described under ‘ What are the benefits of tamoxifen? Some of these side effects can cause death. In one study, in women who still had their uterus: Out of every 1000 women who took a placebo, each year 1 got endometrial cancer (cancer of the lining of the uterus) and none got uterine sarcoma (cancer of the body of the uterus). Out of every 1000 women who took tamoxifen, each year 2 got endometrial cancer and fewer than 1 got uterine sarcoma. These results show that, on average, in high-risk women who still had their uterus , tamoxifen citrate doubled the chance of getting endometrial cancer from 1 in 1000 to 2 in 1000, and it increased the chance of getting uterine sarcoma. This does not mean that taking tamoxifen will double your personal chance of getting endometrial cancer or increase your chance of getting uterine sarcoma. We do not know what this risk will be for any one woman. The risk is different for women who no longer have their uterus. For all women in this study, taking tamoxifen increased the risk of having a blood clot in their lungs or veins, or of having a stroke. In some cases, women died from these effects. Tamoxifen increased the risk of getting cataracts (clouding of the lens of the eye) or needing cataract surgery. Studies are being done to learn more about the long-term benefits and risks of using tamoxifen to reduce the chance of getting breast cancer. What are the possible side effects of tamoxifen? The most common side effect of tamoxifen is hot flashes. This is not a sign of a serious problem.
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