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In this way, we have an up-to-date database of the latest contact information and vital status of the NBS participants. This linkage does not provide information on causes of death, neither can we obtain these data due to a lack of informed consent. What has it found? Key findings and publications. The first paper based on NBS data was published in 2006, which was about thyroid function and presence of anti-thyroperoxidase antibodies in the NBS. An up-to-date list can be found on our website [www. The papers cover a wide range of topics, as there is a large variety of demographic, clinical, biochemical and genetic variables available. The project team of the NBS itself is focused on research into bladder cancer, atherosclerosis and cardiovascular risk factors, disorders of iron metabolism and psychiatric disorders in the adult population (like attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders). The NBS has contributed genetic data to many international consortia that studied genome-wide DNA variation in relation to binary disease phenotypes, using the NBS participants as a control group, and quantitative traits. This has led to the identification of novel associations between DNA variants and a whole range of traits and diseases, for example urinary bladder cancer, 19’22 schizophrenia 23 and educational attainment. An example is a Mendelian randomization study that indicated that iron traits might play a role in atherosclerosis. Phenotypic data from NBS have also been used in many epidemiological studies. Reference values have been constructed for thyroid function, 18 glomerular filtration rate 29 , 30 and hepcidin. What are the main strengths and weaknesses? The NBS was designed to obtain a universal reference population and it has been extremely valuable as such. A main strength of NBS is that the participants are very well phenotyped, with data on a wide variety of variables, phenotypical, environmental and biochemical; NBS thus provides a very rich source of information on a broad range of research questions. In addition, data collection in consecutive phases has allowed collection of information on additional topics that were not covered in NBS-1. Besides, the NBS database has been linked to databases of the Netherlands Cancer Registry, increasing the amount of data available for analysis even further. The NBS is also a relatively large study population, containing questionnaire data on almost 10 000 participants and genomics data for more than 5000 participants. Finally, contact information and vital status of the NBS participants living in the original catchment area have been kept up to date using information on mutations from the register of the municipality of Nijmegen which is sent to us on a regular basis. NBS participants are thus approachable for future research as a source population for new studies. For example, NBS is currently participating in the Biobank Netherlands Internet Collaboration (BIONIC) study [http://www. All participants of the NBS were inhabitants of the municipality of Nijmegen at the time of inclusion. Thus, the NBS represents the population of the eastern part of The Netherlands, steroids-uk.com scamadviser. How well the NBS represents the source population and the Dutch population has not formally been studied.
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